Today, there is a worldwide trend of steadily increasing mortality from occlusive vascular disease, especially cerebrovascular disease, which ranks third among the causes of death. This is due to the increasing number of elderly and geriatric patients. Looking at it from another angle, many 40-year-olds have atherosclerotic lesions of the large arteries of the head, which require clinical observation.

The simplest and at the same time informative noninvasive method of diagnosing peripheral vaso-occlusive lesions appears to be the 3D NLS method, which has entered clinical practice only in the last few years. Using this method, we can assess the condition of the great vessels of the lower extremities and some parts of the brachiocephalic vessels.

Not only the condition of blood vessels but also the condition of deep vein valve devices can be investigated. 205 patients were examined to reveal valvular insufficiency in deep veins affected by varicose veins. Patients ranged in age from 20 to 69 years. Among the patients examined were 52 males (25.4%) and 153 females (74.6%). The investigation was carried out with the "Biophilia Intruder" device, which features 3D visualization of organs and tissues using digitally triggered sensors operating at a frequency of 4.9 GHz. Femoral valvular insufficiency was found in 63 patients, and femoral and popliteal insufficiency was diagnosed in 87 patients. 3D NLS enables non-invasive and objective assessment of the status of deep venous valve devices of the lower extremities, which is important for the chosen surgical strategy and can be used as an alternative to venography.

The spectral entropy analysis method of Biophilia Intruder (SEA) has no contraindications and is comparable to angiography in terms of information. It can be used for screening during the initial examination to reveal early or latent forms of vascular disease and also as an initial method in selecting patients for vascular surgery. Surgical candidates selected after 3D NLS survey. However, this method cannot assess the volumetric properties of blood flow because the 3D NLS of Biophilia Intruder cannot provide true vessel imaging and thus cannot measure blood vessels. This information can be received by a Doppler system with two-dimensional imaging, which provides duplex and triplex scanning (so-called Doppler color chart).